Study on the Properties and Stability of Neotame

Abstract: Neotame is a potent dipeptide sweetener, a derivative of aspartame—and to date, it remains the world's sweetest synthetic sweetener. This study investigated neotame's solubility at various temperatures and its dissolution rate when mixed with sodium saccharin. The results showed that higher temperatures accelerate dissolution, and mixing with sodium saccharin further enhances the dissolution speed. Furthermore, high-performance liquid chromatography was employed to determine neotame's behavior under different conditions. pH Values were measured to assess the stability of neotame under varying conditions—specifically, in aqueous solutions and at different temperatures over time—across diverse systems and environmental settings. The results indicate that neotame exhibits greater stability in acidic and neutral aqueous solutions, while it becomes highly unstable under slightly alkaline conditions. 40 Tian Shi's retention rate is lower than 10% Neotame is in 100 Below ℃ and exhibits excellent short-term high-temperature stability, in 100 When the temperature exceeds ℃, as time increases and the temperature rises, neotame becomes increasingly unstable.

Keywords: Neotame, aspartame, high-performance liquid chromatography, stability

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